Pharmacology And Toxicology Of 1,1-Dimethyl-Hydrazine (UDMH)

Item

Title
Pharmacology And Toxicology Of 1,1-Dimethyl-Hydrazine (UDMH)
Date
1962
Index Abstract
Not Available
Photo Quality
Complete
Report Number
AMRL TDR 62-118
Creator
Back, Kenneth C.
Thomas, Anthony A.
Corporate Author
Aerospace Medical Research Labs Wright-Patterson AFB Ohio
Laboratory
Biomedical Laboratory
Extent
12
Identifier
AD0292689
Access Rights
OTS
Distribution Classification
1
Contract
Laboratory Research - No Contract
DoD Project
6302
DoD Task
630202
DTIC Record Exists
No
Distribution Change Authority Correspondence
None
Distribution Conflict
No
Cover Price
0.5
Abstract
The acute LD50 of UDMH in mice, rats, dogs and monkeys by intraperitoneal administration was found to be 125 mg/kg, 104 mg/kg, 60-100 mg/kg, and 60-100 mg/kg, respectively. All animals exhibited clonic-tonic convulsions as the predominant symptom, and death was via respiratory arrest. Dogs and monkeys routinely showes emesis within 15-60 minutes following dose of UDMH, regardless of rout. In the anesthetized dog UDMH did not alter the effects of epinephrine, norepinephrine, acetylcholine, histamine, or resperine on blood pressure. It did not significantly affect autonomic ganglia or postganglionic nerve endings, nor did it markedly alter the electrocardiogram or blood pressure in 1-2 hours. In the unanestetized dog, however, blood pressure was significantly increased until convulsions and respiratory arrest occurred.
Report Availability
Full text available
Date Issued
1962-10
Provenance
Lockheed Martin Missiles & Fire Control
Type
report
Format
1 online resource
Media
AMRLTDR62-118.pdf

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