Title

Fate of UDMH and MMH in Rats

Date

1964

Index Abstract

Not Available

Photo Quality

Not Needed

Report Number

AMRL TR 64-111

Corporate Author

Oregon State University

Laboratory

Biomedical Laboratory

Extent

28

Identifier

AD0610569

Access Rights

CFSTI

Distribution Classification

1

Contract

AF 33(657)-11757

DoD Project

6302

DoD Task

630202

DTIC Record Exists

No

Distribution Change Authority Correspondence

None

Distribution Conflict

No

Abstract

Many of the applications of hydrazines, especially as rocket propellants and in medicine, give them considerable toxicological importance. The respiratory and urinary excretion by rats of unsymmetrical dimethylhydrazine (UDMH) and monomethylhydrazine (MMH) and their metabolites has been studied by means of radiotracer techniques. At a very low dose, almost 30% of the C14 from i.p. administered UDMH-C14 appeared as respiratory C14O2 in 10 hours. At a convulsive dose, the conversion of UDMH-C14 to C14O2 amounted to slightly greater than 13% at the end of 20 hours. At all doses studied radioactivity appeared in the urine to the extent of at least 50% of the administered UDMH-C14, at the end of two days after administration. Rats administered MMH-C14 by i. p. injection at 20% of a median lethal dose respired approximately 45% of the administered radioactivity in 24 hours. The respired radioactivity consisted of at least two components; 20-25% was C14O2, and the remainder was a C14 labeled volatile compound tentatively identified as methane-C14. At the sub-convulsive doses, 40% of the administered radioactivity in MMH-C14 was excreted in urine. At a toxic dose the percentage of urinary excretion of C14 decreased, but net molar excretion increased slightly. The design of an animal radiorespirometric system capable of continuously monitoring C14 in respiratory gases from separate animals is described.

Report Availability

Full text available

Date Issued

1964-12

Provenance

RAF Centre of Aviation Medicine

Type

report

Format

1 online resource

Creator

Reed, D. J.

Dost, F. N.

Wang, C. H.