columbus · Screening of New Chelating Agents for Beryllium

Screening of New Chelating Agents for Beryllium

Title: Screening of New Chelating Agents for Beryllium
Date: 1965
Index Abstract: Not Available
Photo Quality: Not Needed
Report Number: AMRL TR 65-135
Creator: Sterner, Wolfgang; Loveless, L. E.
Corporate Author: International Bio-Research, Inc.
Laboratory: Aerospace Medical Research Laboratories
Extent: 30
Identifier: AD0623321
Access Rights: CFSTI
Distribution Classification: 1
Contract: AF 33(615)-1804
DoD Project: 6302
DoD Task: 630202
DTIC Record Exists: Yes
Distribution Change Authority Correspondence: None
Distribution Conflict: No
Abstract: Thirteen polyaminopolycarboxylic acid chelating agents were evaluated in vitro and in vivo as potential therapeutic agents for acute beryllium poisoning. In the in vitro test system the ability of the chelating agent to reverse beryllium induced inhibition of alkaline phosphate was measured. In the in vivo system, the chelating agent was evaluated by its ability to prevent mortality of rats that had received an acute lethal dose of beryllium sulfate. None of the polyaminopolycarboxylic acids reversed completely the inhibition of alkaline phosphatase at either 35 percent or 65 percent levels of inhibition. All compounds were ineffective in overcoming the toxic dose of beryllium in rats.
Report Availability: Full text available
Date Issued: 1965-08
Provenance: RAF Centre of Aviation Medicine
Type: report
Format: 1 online resource