Title

Distribution and Excretion of 14C-Monomethylhydrazine

Date

1967

Index Abstract

Not Available

Photo Quality

Not Needed

Report Number

AMRL TR 67-175

Creator

Pinkerton, Mildred K.

Hagan, Edgar A.

Back, Kenneth C.

Corporate Author

Aerospace Medical Research Laboratories

Laboratory

Aerospace Medical Research Laboratories

Extent

24

Identifier

AD0666662

Access Rights

Distribution of this document is unlimited. It may be released to the Clearinghouse, Department of Commerce, for sale to the general public.

Distribution Classification

1

Contract

Laboratory Research - No Contract

DoD Project

6302

DoD Task

630202

DTIC Record Exists

Yes

Distribution Change Authority Correspondence

None

Distribution Conflict

No

Abstract

A total of 20 mice, 20 rats, 17 dogs, and 16 monkeys received intraperitoneal injections of 14C-monomethylhydrazine (MMH) at doses of 22 mg/kg (mice), 15 mg/kg (rats), and 10 mg/kg (monkeys and dogs). At 2, 4, 8, and 24 hours after exposure, representative samples of approximately 20 tissues from each animal were processed for 14C assay using liquid scintillation counting techniques. Both blood and urine samples were simultaneously analyzed by a chemical colorimetric method for unchanged MMH, and the results were correlated with total 14C content. Results of the 14C assays indicated that the mouse, rat, and monkey excreted twice as much as the dog in the first 2 hours, and that all 4 species excreted 25-40% of the total dose by 24 hours after injection. Approximately 50% of the total 14C excretion, at all experimental times, was apparently unchanged MMH as implied by the colorimetric results. Tissue distribution of 14C showed the highest concentrations in liver, kidney, bladder, pancreas, and blood serum. Both clinically and pathologically, the dog was apparently much more susceptible than the other species tested to the toxic effects of MMH and to severe kidney damage.

Report Availability

Full text available

Date Issued

1967-11

Provenance

RAF Centre of Aviation Medicine

Type

report

Format

1 online resource