Title

Study Of The Intermediary Metabolic Pathways Of 1,1-Dimethylhydrazine (UDMH)

Date

1962

Index Abstract

Not Available

Photo Quality

Not Needed

Report Number

AMRL TDR 62-110

Creator

Mitz, Milton A.

Aldrich, F. L.

Vasta, B. M.

Corporate Author

Melpar Inc Falls Church VA

Laboratory

Biomedical Laboratory

Extent

26

Identifier

AD0290509

Access Rights

ASTIA

Distribution Classification

1

Contract

AF 33(616)-8455

DoD Project

6302

DoD Task

630202

DTIC Record Exists

Yes

Distribution Change Authority Correspondence

None

Distribution Conflict

No

Abstract

The metabolic fate of 1,1-dimethylhydrazine (UDMH) was studied in female rats and dogs. The animals were given intraperitoneal injections of C14 labelled UDMH and, after an appropriate time, body tissues were examined by paper chromatography. Six compounds were found, although not all appeared in every tissue. Three major compounds were present in urine. Identification showed one (3-10%) to be the glucose hydrazone of UDMH, and another appeared to be unreacted UDMH (50-60%). The structure of the third major component (20-25%) was not determined, although its chemical and chromatographic behavior suggested that it was a hydrazone or hydrazide of a compound of higher molecular weight than acetic or pyruvic acid. Various analytical procedures were employed for the determination of UDMH in urine, and the trisodium pentacyanoaminoferroate (TPF) procedure was found to be the most sensitive and most specific qualitative method of those tested.

Report Availability

Full text available

Date Issued

1962-09

Provenance

Lockheed Martin Missiles & Fire Control

Type

report

Format

1 online resource