Title

Pharmacology And Toxicology Of 1,1-Dimethyl-Hydrazine (UDMH)

Date

1962

Index Abstract

Not Available

Photo Quality

Complete

Report Number

AMRL TDR 62-118

Creator

Back, Kenneth C.

Thomas, Anthony A.

Corporate Author

Aerospace Medical Research Labs Wright-Patterson AFB Ohio

Laboratory

Biomedical Laboratory

Extent

12

Identifier

AD0292689

Access Rights

OTS

Distribution Classification

1

Contract

Laboratory Research - No Contract

DoD Project

6302

DoD Task

630202

DTIC Record Exists

No

Distribution Change Authority Correspondence

None

Distribution Conflict

No

Cover Price

0.5

Abstract

The acute LD50 of UDMH in mice, rats, dogs and monkeys by intraperitoneal administration was found to be 125 mg/kg, 104 mg/kg, 60-100 mg/kg, and 60-100 mg/kg, respectively. All animals exhibited clonic-tonic convulsions as the predominant symptom, and death was via respiratory arrest. Dogs and monkeys routinely showes emesis within 15-60 minutes following dose of UDMH, regardless of rout. In the anesthetized dog UDMH did not alter the effects of epinephrine, norepinephrine, acetylcholine, histamine, or resperine on blood pressure. It did not significantly affect autonomic ganglia or postganglionic nerve endings, nor did it markedly alter the electrocardiogram or blood pressure in 1-2 hours. In the unanestetized dog, however, blood pressure was significantly increased until convulsions and respiratory arrest occurred.

Report Availability

Full text available

Date Issued

1962-10

Provenance

Lockheed Martin Missiles & Fire Control

Type

report

Format

1 online resource