Title

Investigation Of Compounds Of High Caloric Density

Date

1962

Index Abstract

Not Available

Photo Quality

Undetermined

Report Number

MRL TDR 62-35

Creator

Miller, S. A.

Dymsza, H. A.

Corporate Author

Massachusetts Institute of Technology

Identifier

AD0284004

Access Rights

Unknown

Distribution Classification

1

DTIC Record Exists

No

Distribution Change Authority Correspondence

None

Abstract

Synthesis of 2,4-dimethylheptanoic acid has been completed. Preliminary acute toxicity tests indicated that 2,4-dimethylheptanoic acid has a low order of toxicity (LD(50)-5 gm/kg) similar to other short-chain fatty acids. To facilitate metabolic studies, synthesis of the compound labeled C(14) has begun and techniques for quantitative identification of probable metabolic products have been developed. Further studies were made of the factors influencing the caloric bio-assay. A series of animal metabolic studies has indicated that odd-carbon fatty acids may be partly glucogenic. In addition, 1,3-butanediol was utilized for energy at approximately 6.0 cal/gm in high-fat diets. The slower growth of animals fed this compound at levels up to 20 percent of the diet was due to decreased food intake. Seven-month feeding tests have verified the the effectiveness of 1,3-butanediol and high-fat levels for dietary use under various conditions.

The abstract for this report is either unavailable or has yet to be entered

Report Availability

Full text available by request

Date Issued

1962-05

Provenance

Agricultural Research Service Southern Region Research Center

Type

report