Fate of UDMH and MMH in Rats

Item

Title
Fate of UDMH and MMH in Rats
Date
1964
Index Abstract
Not Available
Photo Quality
Not Needed
Report Number
AMRL TR 64-111
Corporate Author
Oregon State University
Laboratory
Biomedical Laboratory
Extent
28
Identifier
AD0610569
Access Rights
CFSTI
Distribution Classification
1
Contract
AF 33(657)-11757
DoD Project
6302
DoD Task
630202
DTIC Record Exists
No
Distribution Change Authority Correspondence
None
Distribution Conflict
No
Abstract
Many of the applications of hydrazines, especially as rocket propellants and in medicine, give them considerable toxicological importance. The respiratory and urinary excretion by rats of unsymmetrical dimethylhydrazine (UDMH) and monomethylhydrazine (MMH) and their metabolites has been studied by means of radiotracer techniques. At a very low dose, almost 30% of the C14 from i.p. administered UDMH-C14 appeared as respiratory C14O2 in 10 hours. At a convulsive dose, the conversion of UDMH-C14 to C14O2 amounted to slightly greater than 13% at the end of 20 hours. At all doses studied radioactivity appeared in the urine to the extent of at least 50% of the administered UDMH-C14, at the end of two days after administration. Rats administered MMH-C14 by i. p. injection at 20% of a median lethal dose respired approximately 45% of the administered radioactivity in 24 hours. The respired radioactivity consisted of at least two components; 20-25% was C14O2, and the remainder was a C14 labeled volatile compound tentatively identified as methane-C14. At the sub-convulsive doses, 40% of the administered radioactivity in MMH-C14 was excreted in urine. At a toxic dose the percentage of urinary excretion of C14 decreased, but net molar excretion increased slightly. The design of an animal radiorespirometric system capable of continuously monitoring C14 in respiratory gases from separate animals is described.
Report Availability
Full text available
Date Issued
1964-12
Provenance
RAF Centre of Aviation Medicine
Type
report
Format
1 online resource
Creator
Reed, D. J.
Dost, F. N.
Wang, C. H.