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Title
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Antiarrhythmic Activity of Antazoline and its Application to the Control of Hypothermic Ventricular Fibrillation
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Date
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1965
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Index Abstract
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Not Available
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Photo Quality
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Not Needed
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Report Number
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AMRL TR 65-201
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Creator
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Angelakos, E. T.
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Corporate Author
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Boston University School of Medicine
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Laboratory
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Aerospace Medical Research Laboratories
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Extent
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36
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Identifier
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AD0629548
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Access Rights
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Distribution of this document is unlimited
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Distribution Classification
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1
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Contract
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AF 33(657)-10755
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DoD Project
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7164
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DoD Task
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716409
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DTIC Record Exists
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No
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Distribution Change Authority Correspondence
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None
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Distribution Conflict
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No
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Abstract
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The chemistry and general pharmacology of antazoline and experimental studies employing it are reviewed to determine the antiarrhythmic activity and the protective effect of antazoline against hypothermic ventricular fibrillation. In hypothermic ventricular fibrillation and in clinically observed heart disorders, the antiarrhythmic activity of antazoline was often superior to other pharmacological agents, including quinidine. The incidence of side effects, notably nausea or vomiting, was found to be related to the dosage. Since the basis of the antiarrhythmic activity of antazoline is essentially unknown, further studies in this direction are warranted to provide for systematic development of more effective compounds.
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Report Availability
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Full text available
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Date Issued
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1965-12
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Provenance
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RAF Centre of Aviation Medicine
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Type
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report
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Format
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1 online resource
AMRLTR65-201.pdf