Acute Heptotoxicity and Enzymantic Response to Hydrazine and 1,1-Dimethylhydrazine in Rats

Item

Title
Acute Heptotoxicity and Enzymantic Response to Hydrazine and 1,1-Dimethylhydrazine in Rats
Date
1965
Index Abstract
Not Available
Photo Quality
Complete
Report Number
AMRL TR 65-19
Creator
Reinhardt, Charles F.
Pinkerton, Mildred K.
Corporate Author
Ohio State University
Laboratory
Biomedical Laboratory
Extent
40
Identifier
AD0614587
Access Rights
CFSTI
Distribution Classification
1
Contract
AF 33(657)-1698
DoD Project
6302
DoD Task
None Given
DTIC Record Exists
Yes
Distribution Change Authority Correspondence
None
Distribution Conflict
No
Abstract
The in vivo and in vitro effects of hydrazine and of 1, 1-dimethylhydrazine (UDMH) on blood serum and liver tissue enzyme activities were studied. The specific enzymes investigated were lactic dehydrogenase, isocitric dehydrogenase, malic dehydrogenase, and glumatic acid dehydrogenase. Activity levels were determined at 16, 24, 48, and 72 hours after intraperitoneal administration of the toxic agents to rats. Attempts were made to correlate enzyme levels with altered liver pathology. Results were compared with a concomitant study of the effects of carbon tetrachloride on the same enzymes and on liver pathology. Results indicated that the mechanisms of toxic action for these three chemical agents are probably dissimilar and that serum enzyme levels may not provide sensitive indications of altered liver pathology in the case of hydrazine or UDMH.
Report Availability
Full text available
Date Issued
1965-02
Provenance
RAF Centre of Aviation Medicine
Type
report
Format
1 online resource
Media
AMRLTR65-019.pdf