Screening of New Chelating Agents for Beryllium

Item

Title
Screening of New Chelating Agents for Beryllium
Date
1965
Index Abstract
Not Available
Photo Quality
Not Needed
Report Number
AMRL TR 65-135
Creator
Sterner, Wolfgang
Loveless, L. E.
Corporate Author
International Bio-Research, Inc.
Laboratory
Aerospace Medical Research Laboratories
Extent
30
Identifier
AD0623321
Access Rights
CFSTI
Distribution Classification
1
Contract
AF 33(615)-1804
DoD Project
6302
DoD Task
630202
DTIC Record Exists
Yes
Distribution Change Authority Correspondence
None
Distribution Conflict
No
Abstract
Thirteen polyaminopolycarboxylic acid chelating agents were evaluated in vitro and in vivo as potential therapeutic agents for acute beryllium poisoning. In the in vitro test system the ability of the chelating agent to reverse beryllium induced inhibition of alkaline phosphate was measured. In the in vivo system, the chelating agent was evaluated by its ability to prevent mortality of rats that had received an acute lethal dose of beryllium sulfate. None of the polyaminopolycarboxylic acids reversed completely the inhibition of alkaline phosphatase at either 35 percent or 65 percent levels of inhibition. All compounds were ineffective in overcoming the toxic dose of beryllium in rats.
Report Availability
Full text available
Date Issued
1965-08
Provenance
RAF Centre of Aviation Medicine
Type
report
Format
1 online resource