Title

Screening of New Chelating Agents for Beryllium

Date

1965

Index Abstract

Not Available

Photo Quality

Not Needed

Report Number

AMRL TR 65-135

Creator

Sterner, Wolfgang

Loveless, L. E.

Corporate Author

International Bio-Research, Inc.

Laboratory

Aerospace Medical Research Laboratories

Extent

30

Identifier

AD0623321

Access Rights

CFSTI

Distribution Classification

1

Contract

AF 33(615)-1804

DoD Project

6302

DoD Task

630202

DTIC Record Exists

Yes

Distribution Change Authority Correspondence

None

Distribution Conflict

No

Abstract

Thirteen polyaminopolycarboxylic acid chelating agents were evaluated in vitro and in vivo as potential therapeutic agents for acute beryllium poisoning. In the in vitro test system the ability of the chelating agent to reverse beryllium induced inhibition of alkaline phosphate was measured. In the in vivo system, the chelating agent was evaluated by its ability to prevent mortality of rats that had received an acute lethal dose of beryllium sulfate. None of the polyaminopolycarboxylic acids reversed completely the inhibition of alkaline phosphatase at either 35 percent or 65 percent levels of inhibition. All compounds were ineffective in overcoming the toxic dose of beryllium in rats.

Report Availability

Full text available

Date Issued

1965-08

Provenance

RAF Centre of Aviation Medicine

Type

report

Format

1 online resource