1, 1-Dimethylhydrazine Effects on Central Excitatory and inhibitory Mechanisms in Cats

Item

Title
1, 1-Dimethylhydrazine Effects on Central Excitatory and inhibitory Mechanisms in Cats
Date
1965
Index Abstract
Not Available
Photo Quality
Not Needed
Report Number
AMRL TR 65-142
Creator
Fairchild, M. D.
Sterman, M. B.
Corporate Author
University of California, Los Angeles
Laboratory
Aerospace Medical Research Laboratories
Extent
39
Identifier
AD0623786
Access Rights
CFSTI
Distribution Classification
1
Contract
AF 41(609)-2329
DoD Project
6302
DoD Task
630202
DTIC Record Exists
Yes
Distribution Change Authority Correspondence
None
Distribution Conflict
No
Abstract
Experiments, using cats with chronically implanted brain electrodes, were performed to explore the influence of subconvulsive doses of 1, 1- dimethylhydrazine (UDMH) on certain excitatory and inhibitory mechanisms in the central nervous system (CNS). The cats were stimulated electrically in the midbrain reticular activating system, the basal forebrain inhibitory area, and both areas simultaneously while the animal was tested for performance in a positively reinforced experimental situation. UDMH was compared with amphetamine, chlorpromazine and phenobarbital both in the presence and absence of CNS stimulation. UDMH acted in a manner similar to chlorpromazine in subconvulsive doses in these tests. The most interesting and consistent effect of UDMH was to abort performance when the basal forebrain inhibitory area was stimulated. The animals resumed performance when the stimulus was terminated. UDMH has detectable CNS effects at doses well below convulsive levels.
Report Availability
Full text available
Date Issued
1965-08
Provenance
RAF Centre of Aviation Medicine
Type
report
Format
1 online resource