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Title
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1, 1-Dimethylhydrazine Effects on Central Excitatory and inhibitory Mechanisms in Cats
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Date
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1965
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Index Abstract
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Not Available
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Photo Quality
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Not Needed
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Report Number
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AMRL TR 65-142
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Creator
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Fairchild, M. D.
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Sterman, M. B.
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Corporate Author
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University of California, Los Angeles
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Laboratory
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Aerospace Medical Research Laboratories
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Extent
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39
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Identifier
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AD0623786
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Access Rights
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CFSTI
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Distribution Classification
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1
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Contract
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AF 41(609)-2329
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DoD Project
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6302
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DoD Task
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630202
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DTIC Record Exists
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Yes
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Distribution Change Authority Correspondence
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None
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Distribution Conflict
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No
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Abstract
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Experiments, using cats with chronically implanted brain electrodes, were performed to explore the influence of subconvulsive doses of 1, 1- dimethylhydrazine (UDMH) on certain excitatory and inhibitory mechanisms in the central nervous system (CNS). The cats were stimulated electrically in the midbrain reticular activating system, the basal forebrain inhibitory area, and both areas simultaneously while the animal was tested for performance in a positively reinforced experimental situation. UDMH was compared with amphetamine, chlorpromazine and phenobarbital both in the presence and absence of CNS stimulation. UDMH acted in a manner similar to chlorpromazine in subconvulsive doses in these tests. The most interesting and consistent effect of UDMH was to abort performance when the basal forebrain inhibitory area was stimulated. The animals resumed performance when the stimulus was terminated. UDMH has detectable CNS effects at doses well below convulsive levels.
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Report Availability
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Full text available
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Date Issued
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1965-08
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Provenance
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RAF Centre of Aviation Medicine
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Type
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report
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Format
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1 online resource
AMRLTR65-142.pdf