Oxygen Transport Through Hemoglobin Solutions

Item

Title
Oxygen Transport Through Hemoglobin Solutions
Date
1966
Index Abstract
Not Available
Photo Quality
Not Needed
Report Number
AMRL TR 66-19
Creator
Hammel, Harold T.
Corporate Author
John B. Pierce Foundation Laboratory
Laboratory
Aerospace Medical Research Laboratories
Extent
24
Identifier
AD0635623
Access Rights
Distribution of this document is unlimited
Distribution Classification
1
Contract
AF 33(657)-11103
DoD Project
7164
DoD Task
716409
DTIC Record Exists
No
Distribution Change Authority Correspondence
None
Distribution Conflict
No
Abstract
Scholander discovered that the steady state flux of oxygen through a thin film of water could be enhanced many times by adding hemoglobin to the water. Several authors have ascribed this facilitated flux of oxygen to the diffusion of oxyhemoglobin down its gradient although the details of their formulations have not been rigorously supported by experimental evidence. A series of measurements of oxygen and nitrogen flux through a film of hemoglobin solution were made for which the pO2 and pN2 on6ne side were always 16.5 and 62.5 mm Hg respectively while the pO2 on the other side was increased from 0.5 to 14 mm Hg by adding increasing thicknesses of teflon film to this side. When the facilitated oxygen flux was small, it was found to equal the calculated flux assuming that the oxygen was carried by the diffusing oxyhemoxglobin and that Henry's law and the equilibrium dissociation curve for oxyhemoglobin apply at the two surfaces of the hemoglobin film. When the facilitated oxygen flux was greatest, it was found to be only one half the calculated flux, presumably because the pO2 on the solution side of the gas-solution interface was considerably less than the 16.5 mmHg prevailing on the gas side.
Report Availability
Full text available
Date Issued
1966-02
Provenance
RAF Centre of Aviation Medicine
Type
report
Format
1 online resource
Media
AMRLTR66-019.pdf