Title

Pathology of Oxygen Toxicity in Forty Macaca Mulatta

Date

1967

Index Abstract

Not Available

Photo Quality

Complete

Report Number

AMRL TR 66-234

Creator

Robinson, Farrel R.

Harper, David T.

Kaplan, Harold P.

Thomas, Anthony A.

Corporate Author

Biomedical Laboratory

Laboratory

Biomedical Laboratory

Extent

22

Identifier

AD0653526

Access Rights

Distribution of this document is unlimited

Distribution Classification

1

Contract

Laboratory Research - No Contract

DoD Project

6302

DoD Task

630206

DTIC Record Exists

Yes

Distribution Change Authority Correspondence

None

Distribution Conflict

No

Abstract

Forty monkeys (Macaca mulatta) were exposed to 99-100% oxygen at pressures from 600 to 760 mm Hg. The acute exudative pulmonary response was seen in only three exposed at 760 mm Hg. The subacute proliferative pulmonary response was seen at all levels studied, the degree being directly related to time-dose exposures. In the high dose ranges clinical signs of illness were evident after 5-7 days exposure when the monkeys became listless and anoretic. By 14 days they were quite lethargic and had assumed a huddled position. Grossly, the heavy lungs had a gray, bloodless appearance. Microscopically, there was extreme proliferation of the interstitium and alveolar epithelium. None of the monkeys that were exposed at 600 mm Hg died, although mild focal proliferative changes were seen. After 31 days postexposure, these changes appeared as focal areas of atelectasis with mild septal fibrosis.

Report Availability

Full text available

Date Issued

1967-03

Provenance

RAF Centre of Aviation Medicine

Type

report

Format

1 online resource