Title

Effect of Hydrazines on Vitamin B6 Levels in the Mouse Brain

Date

1966

Index Abstract

Not Available

Photo Quality

Not Needed

Report Number

AMRL TR 66-135

Creator

Furst, Arthur

Gustavson, Waldemar R.

Corporate Author

University of San Francisco

Laboratory

Aerospace Medical Research Laboratories

Extent

46

Identifier

AD0647192

Access Rights

Distribution of this document is unlimited

Distribution Classification

1

Contract

AF 33(615)-2332

DoD Project

6302

DoD Task

630202

DTIC Record Exists

No

Distribution Change Authority Correspondence

None

Distribution Conflict

No

Abstract

The effects of administered 1,1-dimethylhydrazine (UDMH) and monomethylhydrazine (MMH) on vitamin B6 levels in mouse brain have been studied. Separation of the B6 group (pyridoxol, pyridoxal, pyridoxamine, and the respective 5-phosphates) by means of paper chromatography revealed that the R sub F values obtained are dependent upon the pH of the developing solvent. To obtain the time lag just prior to convulsions induced by UDMH and MMH, a dose-lag time study was conducted; included were pyridoxal and (its 5-phosphate) hydrazones of UDMH and MMH. Graphs of log dose vs lag time are given. The bioassay procedure, though not completed, permits detection of some of the B6 congeners to a limit of 0.5 nanograms.

Report Availability

Full text available

Date Issued

1966-09

Provenance

RAF Centre of Aviation Medicine

Type

report

Format

1 online resource