Title

Effects of 1, 1-Dimethylhydrazine (UDMH) on Evoked Cerebral Neuroelectric Responses

Date

1967

Index Abstract

Not Available

Photo Quality

Complete

Report Number

AMRL TR 67-67

Creator

Goff, W. R.

Allison, T.

Matsumiya, Y.

Corporate Author

Yale University School of Medicine

Laboratory

Aerospace Medical Research Laboratories

Extent

16

Identifier

AD0663764

Access Rights

Distribution of this document is unlimited. It may be released to the Clearinghouse, Department of Commerce, for sale to the general public.

Distribution Classification

1

Contract

AF 33(615)-2822

DoD Project

6302

DoD Task

630202

DTIC Record Exists

Yes

Distribution Change Authority Correspondence

None

Abstract

The neural mechanisms of UDMH intoxication were studied by analyzing changes in cortical, subcortical, and cerebellar neuroelectric potentials evoked by peripheral nerve stimulation. Results showed that the negative component of the primary somatosensory cortical evoked potential was markedly potentiated by UDMH intoxication while the positive component of this response together with the response from the specific somatic sensory thalamic relay and from the cerebellum were unaffected. The potentiation almost always occurred in the absence of other evoked or spontaneous neuroelectric changes and preceded epileptiform seizure by several minutes. Thus it was usually the sole predictor of seizure. Motor paralysis markedly prolonged seizure onset. These results indicate the UDMH intoxication increases intracortical excitability acting primarily at axo-dendritic synapses to block inhibitory post-synaptic potentials. The resulting positive sensory-motor feedback is an important element in the production of seizures.

Report Availability

Full text available

Date Issued

1967-09

Provenance

RAF Centre of Aviation Medicine

Type

report

Format

1 online resource