Subconvulsive Effects of 1, 1-Dimethylhydrazine on Locomotor Performance in the Cat: Relationship of Dose to Time of Onset

Item

Title
Subconvulsive Effects of 1, 1-Dimethylhydrazine on Locomotor Performance in the Cat: Relationship of Dose to Time of Onset
Date
1967
Index Abstract
Not Available
Photo Quality
Not Needed
Report Number
AMRL TR 67-66
Creator
Sterman, M. B.
Fairchild, M. D.
Corporate Author
University of California, Los Angeles
Laboratory
Aerospace Medical Research Laboratories
Extent
20
Identifier
AD0664549
Access Rights
Distribution of this document is unlimited. It may be released to the Clearinghouse, Department of Commerce, for sale to the general public.
Distribution Classification
1
Contract
AF 33(615)-2822
DoD Project
6302
DoD Task
630202
DTIC Record Exists
Yes
Distribution Change Authority Correspondence
None
Distribution Conflict
No
Abstract
Several recent neurophysiological findings in the study of 1, 1- dimethylhydrazine toxicity have suggested that this substance initiates a gradual increase in central nervous system (CNS) excitability, leading eventually to general convulsions. This process, however, is periodically interrupted by episodes of recovery or suppression of excitability. In the present experiment an attempt was made to investigate the nature of this alternation in response to low doses of UDMH, using the performance of a locomotor task as a measure of CNS effects. Cats were trained and tested in a special runway apparatus to provide a reliable indication of performance changes over a 6 hour period following the administration of 4, 8, and 16 mg/kg UDMH. These low doses significantly altered locomotor performance in a predictable manner. The response to a given dose was both consistent and unique to that dose. Within the 6 hour period of measurement, 16 mg/kg caused a gradual reduction in performance velocity leading to a total disruption, which was then followed by a tendency to recover; 8 mg/kg produced a recurrent depression of velocity followed by an enhancement, and 4 mg/kg resulted in a biphasic depression facilitation response. Other more general findings are also discussed.
Report Availability
Full text available
Date Issued
1967-09
Provenance
RAF Centre of Aviation Medicine
Type
report
Format
1 online resource
Media
AMRLTR67-066.pdf

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