Title

Metabolism and Pharmacology of Inorganic and Fluorine Containing Compounds

Date

1968

Index Abstract

Not Available

Photo Quality

Not Needed

Report Number

AMRL TR 67-224

Creator

Dost, Frank N.

Reed, Donald J.

Finch, Arthur

Wang, Chih H.

Corporate Author

Oregon State University

Laboratory

Aerospace Medical Research Laboratories

Extent

102

Identifier

AD0681161

Access Rights

This document has been approved for public release and sale; its distribution is unlimited.

Distribution Classification

1

Contract

AF 33(615)-1799

DoD Project

6302

DoD Task

630202

DTIC Record Exists

Yes

Distribution Change Authority Correspondence

None

Distribution Conflict

No

Abstract

Studies have been made of the toxicology and chemistry of nitrogen trifluoride, tetrafluorohydrazine, chlorine trifluoride, bromine pentafluoride, and oxygen difluoride. Lethality of each agent by inhalation has been determined, as well as estimates of lethality after intraperitoneal administration. Experimental evidence suggests that the lethal effect of interhalogens is by corrosive local destruction of pulmonary surfaces, resulting in failure of gas exchange. Oxygen difluoride is thought to pass intact into the pulmonary cells where it reacts with biochemical reducing systems to ultimately cause cell death and structural failure. The nitrogen fluorides both cause intrinsically lethal levels of methemoglobin formation, but other pharmacologic activity by these compounds or their derivatives may also contribute to their toxic activity.

Report Availability

Full text available

Date Issued

1968-08

Provenance

RAF Centre of Aviation Medicine

Type

report

Format

1 online resource