Metabolism and Pharmacology of Inorganic and Fluorine Containing Compounds

Item

Title
Metabolism and Pharmacology of Inorganic and Fluorine Containing Compounds
Date
1968
Index Abstract
Not Available
Photo Quality
Not Needed
Report Number
AMRL TR 67-224
Creator
Dost, Frank N.
Reed, Donald J.
Finch, Arthur
Wang, Chih H.
Corporate Author
Oregon State University
Laboratory
Aerospace Medical Research Laboratories
Extent
102
Identifier
AD0681161
Access Rights
This document has been approved for public release and sale; its distribution is unlimited.
Distribution Classification
1
Contract
AF 33(615)-1799
DoD Project
6302
DoD Task
630202
DTIC Record Exists
Yes
Distribution Change Authority Correspondence
None
Distribution Conflict
No
Abstract
Studies have been made of the toxicology and chemistry of nitrogen trifluoride, tetrafluorohydrazine, chlorine trifluoride, bromine pentafluoride, and oxygen difluoride. Lethality of each agent by inhalation has been determined, as well as estimates of lethality after intraperitoneal administration. Experimental evidence suggests that the lethal effect of interhalogens is by corrosive local destruction of pulmonary surfaces, resulting in failure of gas exchange. Oxygen difluoride is thought to pass intact into the pulmonary cells where it reacts with biochemical reducing systems to ultimately cause cell death and structural failure. The nitrogen fluorides both cause intrinsically lethal levels of methemoglobin formation, but other pharmacologic activity by these compounds or their derivatives may also contribute to their toxic activity.
Report Availability
Full text available
Date Issued
1968-08
Provenance
RAF Centre of Aviation Medicine
Type
report
Format
1 online resource