Title

Subconvulsive Effects of Monomethylhydrazine on Runway Performance in the Cat

Date

1969

Index Abstract

Not Available

Photo Quality

Not Needed

Report Number

AMRL TR 68-183

Creator

Sterman, M. B.

Van Twyver, H. B.

Fairchild, M. D.

Corporate Author

University of Califronia, Los Angeles

Laboratory

Aerospace Medical Rsearch Laboratory

Extent

14

Identifier

AD0691473

Access Rights

This document has been approved for public release and sale; its distribution is unlimited

Distribution Classification

1

Contract

AF 33(615)-2822

DoD Project

6302

DoD Task

630202

DTIC Record Exists

No

Distribution Change Authority Correspondence

None

Distribution Conflict

No

Abstract

Previous neurophysiological and behavioral studies of the toxic propellant UDMH have indicated that its subtle-dose influences can be most effectively evaluated in the cat by reference to trained locomotor performance. To determine similar fundamental information in evaluating monomethylhydrazine (MMH), a related derivative of hydrazine, this same technique was employed. Cats were trained and tested in a special runway apparatus to provide a reliable indication of performance changes over a 6-hour period following the administration of 1, 2, and 4 mg/kg MMH. These low doses significantly altered locomotor performance, both during drug session testing and saline control testing carried out 24 hours later. Within 30 minutes after injection of all three doses of MMH, runway performance was depressed. At 2 and 4 mg/kg, this influence was profound and was associated with overt physiological symptoms of toxicity. A total disruption of performance occurred with 4 mg/kg doses when tested 2-5 hours after administration. Performance was still depressed after 24 hours following 4 mg/kg, but was actually facilitated at this same point following 1 and 2 mg/kg doses.

Report Availability

Full text available

Date Issued

1969-06

Provenance

RAF Centre of Aviation Medicine

Type

report

Format

1 online resource