Electroencephalographic and Behavioral Studies of Monomethylhydrazine Toxicity in the Cat

Item

Title
Electroencephalographic and Behavioral Studies of Monomethylhydrazine Toxicity in the Cat
Date
1969
Index Abstract
Not Available
Photo Quality
Not Needed
Report Number
AMRL TR 69-3
Creator
Sterman, M. B.
Fairchild, M. D.
LoPresti, R. W.
Corporate Author
University of Califronia, Los Angeles
Laboratory
Aerospace Medical Research Laboratory
Extent
14
Identifier
AD0691474
Access Rights
This document has been approved for public release and sale; its distribution is unlimited
Distribution Classification
1
Contract
AF 33(615)-2822
DoD Project
6302
DoD Task
630202
DTIC Record Exists
Yes
Distribution Change Authority Correspondence
None
Distribution Conflict
No
Abstract
The toxicity of monomethylhydrazine (MMH) administered intraperitoneally in the cat was studied by reference to behavioral and neurophysiological indices. The acute toxicity LD50 value for MMH was established as 15 mg/kg, and the CD50 as 7 mg/kg. Doses of 18, 9, and 5 mg/kg were then studied systematically in an effort to classify lethal, convulsive and subconvulsive symptoms. For these doses, a preconvulsive syndrome was described involving recurrent and sustained symptoms including vomiting, panting, rapid respiration, viscous salivation, hyperactivity and subcortical seizure activity. The onset latency of these symptoms was directly related to dose. Several lines of evidence suggested at least a partial independence between the biochemical and neurophysiological events responsible, on the one hand, for convulsions, and on the other for this preconvulsive syndrome. Convulsions were specifically delayed or prevented in animals trained to suppress movement through the use of a special EEG conditioning technique.
Report Availability
Full text available
Date Issued
1969-06
Is Referenced By
Toh, Vernice M. Y. Si, "Effect of Neurofeedback on Children with ADHD Symptoms: Case Studies" date unknown
Provenance
RAF Centre of Aviation Medicine
Type
report
Format
1 online resource