Title

Electroencephalographic and Behavioral Studies of Monomethylhydrazine Toxicity in the Cat

Date

1969

Index Abstract

Not Available

Photo Quality

Not Needed

Report Number

AMRL TR 69-3

Creator

Sterman, M. B.

Fairchild, M. D.

LoPresti, R. W.

Corporate Author

University of Califronia, Los Angeles

Laboratory

Aerospace Medical Research Laboratory

Extent

14

Identifier

AD0691474

Access Rights

This document has been approved for public release and sale; its distribution is unlimited

Distribution Classification

1

Contract

AF 33(615)-2822

DoD Project

6302

DoD Task

630202

DTIC Record Exists

Yes

Distribution Change Authority Correspondence

None

Distribution Conflict

No

Abstract

The toxicity of monomethylhydrazine (MMH) administered intraperitoneally in the cat was studied by reference to behavioral and neurophysiological indices. The acute toxicity LD50 value for MMH was established as 15 mg/kg, and the CD50 as 7 mg/kg. Doses of 18, 9, and 5 mg/kg were then studied systematically in an effort to classify lethal, convulsive and subconvulsive symptoms. For these doses, a preconvulsive syndrome was described involving recurrent and sustained symptoms including vomiting, panting, rapid respiration, viscous salivation, hyperactivity and subcortical seizure activity. The onset latency of these symptoms was directly related to dose. Several lines of evidence suggested at least a partial independence between the biochemical and neurophysiological events responsible, on the one hand, for convulsions, and on the other for this preconvulsive syndrome. Convulsions were specifically delayed or prevented in animals trained to suppress movement through the use of a special EEG conditioning technique.

Report Availability

Full text available

Date Issued

1969-06

Is Referenced By

Toh, Vernice M. Y. Si, "Effect of Neurofeedback on Children with ADHD Symptoms: Case Studies" date unknown

Provenance

RAF Centre of Aviation Medicine

Type

report

Format

1 online resource