Effects of Decaborane on Brain Activity

Item

Title
Effects of Decaborane on Brain Activity
Date
1963
Index Abstract
Not Available
Photo Quality
Complete
Report Number
AMRL TDR 63-41
Creator
Delgado, Jose M.
Corporate Author
Yale University
Laboratory
Biomedical Laboratory
Extent
22
Identifier
AD0411769
Access Rights
OTS
Distribution Classification
1
Contract
AF 33(657)-9021
DoD Project
6302
DoD Task
630202
DTIC Record Exists
Yes
Distribution Change Authority Correspondence
None
Distribution Conflict
No
Cover Price
0.75
Abstract
The effects on intraperitoneal injection of decaborane have been investigated in monkeys with electrodes permanently implanted in the brain. One single injection of 5 mg/kg produced a marked behavioral depression, with only moderate electroencephalographic modifications, followed by death in 18 hours. Four daily doses of 3 mg/kg produced depression, somnolence, twitching in both arms, accompanied by bursts of high-voltage activity, localized in the internal capsule. Death occurred 3 days later. Daily doses of 1 mg/kg up to a total of 14 mg/kg pro produced depression, muscular twitching, anorexia, and a typical electroencephalographic pattern, but the animals recovered completely. Depression may be related to reticular system involvement. Motor symptomatology could depend on disturbances of heavily myelinated motor axons which may have a special affinity for the liposoluble decaborane. Hypothalamic involvement was questionable, but neighboring structures, especially the internal capsule showed electrical disturbances.
Report Availability
Full text available
Date Issued
1963-05
Provenance
RAF Centre of Aviation Medicine
Type
report
Format
1 online resource
Media
AMRLTDR63-041.pdf